Amnon Koren has published three papers centered around his work on DNA replication timing. He described a new way to study DNA replication by using increasingly abundant whole genome sequence data, which he found contained signatures of DNA replication processes that were active in cells at the moment DNA was extracted from them. For more information, please check out: Amnon Koren’s papers (1 2 3); News and Views article by Jay Shendure in Cell; HMS video describing the discovery
The mystery had tantalized geneticists for 15 years: scores of genes and millions of bases of human DNA sequence had no home on maps of the human genome. Where in the human genome were they hiding? The mystery is solved – with mathematics – in a paper by Giulio Genovese and colleagues in Nature Genetics.