Concerted neuron-astrocyte gene expression declines in aging and schizophrenia
We study how human genomes vary and how this variation shapes biology.
Using single-cell sequencing, we investigated the mosaic of cells that make up the brain.
Somatic and acquired mutations drive the risk of having a precancerous blood condition.
C4 underlies one of the strongest genetic signals in the risk for schizophrenia.
Senior computational biologist and co-first author, Giulio Genovese, recently published “Genetic drivers and cellular selection of female mosaic X chromosome loss” in Nature. In this study, we explored the genetic causes and health implications of mosaic loss of the X chromosome (mLOX) in females. We analyzed data from over 880,000 […]
Postdoctoral researcher, Emi Ling, published her work on “A concerted neuron-astrocyte program declines in ageing and schizophrenia” in Nature. Ling et al. analyzed the prefrontal cortex of 191 human donors by single-nucleus RNA-seq of postmortem brain tissue samples pooled together in “villages.” We found a striking relationship between cortical neuron […]
In a recent #WhyIScience Q&A Broad news story, principal software engineer, Khalid Shakir, shares his journey from tinkering with spare equipment in his parents’ high school classrooms to pioneering large-scale computational tools, his passion for emerging technologies like AI, and the invaluable role of affinity groups like A4C in fostering […]
Steve McCarroll and lab alumnus, Evan Macosko, were interviewed by the Broad News team about their recently awarded grant from the NIH’s Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative. Their grant aims to create an atlas of human brain cell variation and to better understand what generates that variation. […]
Research presented by Ric del Rosario and lab alumna, Fenna Krienen at Neuroscience 2022, the largest neuroscience conference, was recently showcased by Spectrum, a news outlet for autism research. Ric’s work on microglia chimerism in marmoset brains and Fenna’s work on generating a marmoset brain cell atlas outline new ways […]
