Concerted neuron-astrocyte gene expression declines in aging and schizophrenia
We study how human genomes vary and how this variation shapes biology.
Using single-cell sequencing, we investigated the mosaic of cells that make up the brain.
Somatic and acquired mutations drive the risk of having a precancerous blood condition.
C4 underlies one of the strongest genetic signals in the risk for schizophrenia.
Evan Macosko has been named a top inventor in the MIT Technology Review’s “35 Innovators Under 35” for his work on inventing Drop-seq. Evan’s Drop-seq technology, which he developed during his postdoctoral research in the McCarroll lab, makes it possible to analyze gene expression in thousands of individual cells simultaneously. […]
Articles by Stat News and GEN on our discovery (together with Kevin Eggan’s lab) that pluripotent stem cells routinely acquire dominant-negative mutations in the TP53 gene. Florian Merkle and Sulagna (Dia) Ghosh led the research team.
Steve’s keynote talk at the 22nd Music Festival for Brain Health, on the human genome’s impact on brain health and illness.
NAMI, the National Alliance on Mental Illness, is an organization dedicated to building better lives for Americans affected by mental illness. Each year, it awards scientists who have inspired hope through their research. This year (2016), Steve McCarroll, Beth Stevens, and Mike Carroll were presented with the award at the […]
Arpy Saunders has received a three-year post-doctoral fellowship from the Helen Hay Whitney Foundation (HHW), marking another step on his scientific journey that started in a cabin in the New Hampshire woods. Having grown up there, it is no surprise that, before coming to our lab, he studied outdoorsy science […]
