Concerted neuron-astrocyte gene expression declines in aging and schizophrenia
We study how human genomes vary and how this variation shapes biology.
Using single-cell sequencing, we investigated the mosaic of cells that make up the brain.
Somatic and acquired mutations drive the risk of having a precancerous blood condition.
C4 underlies one of the strongest genetic signals in the risk for schizophrenia.
The biological basis for most brain disorders is unknown today: most are conceptualized mainly in terms of collections of symptoms, neuropathological observations, and human-genetic associations. We need to deeply understand these disorders as biological entities so that we can develop new and innovative ways to monitor and treat them.
Our lab is focused on (i) DNA-repeat disorders and (ii) the disruptions of mental health commonly known as “psychiatric disorders,” especially schizophrenia.
Our research team brings together people with experiences, approaches and insights from biology, human genetics, statistics, and computer science.
Two new papers from the McCarroll lab describe ways of using nanoliter droplets to answer questions in genetics and biology. Droplets provide a way of scaling molecular biological reactions across tens of thousands of tiny reaction compartments. In Drop-phase, Jack Regan, Nolan Kamitaki and colleagues describe a way to quickly […]
A common, pre-cancerous state can precede cancer by many years and is readily detectable by DNA sequencing, according to a new paper by Giulio Genovese and colleagues in the New England Journal of Medicine.
A process as fundamental as replication of a genome varies from person – shaped by common, inherited genetic variation that can also affect risk of cancer. The work is described in a new paper by Amnon Koren and colleagues in Cell.
Amnon Koren has published three papers centered around his work on DNA replication timing. He described a new way to study DNA replication by using increasingly abundant whole genome sequence data, which he found contained signatures of DNA replication processes that were active in cells at the moment DNA was extracted from them. For more information, please check out: Amnon Koren’s papers (1 2 3); News and Views article by Jay Shendure in Cell; HMS video describing the discovery
Macosko will continue his work to develop “Drop-Seq”, a technology for profiling gene expression in thousands of single cells at once.
